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Laboratory of Biotechnology

Head of Laboratory, Doctor, Professor E.Kirtadze

Contacts

Phone: (995 32) 528026
Å-mail: kirtadze@mail.ru

Main Directions

Selection of microorganisms from various taxonomic groups (mold fungi, bacteria, yeasts) growing in ordinary and extreme conditions.
Creation of  metabolically active mutants, fusants and transformants.
Creation of the collection of microbial strains growing in extreme conditions and isolation of enzymes resistant to critical conditions, study of their physical -chemical characteristics.
Study of detoxification potential of  microorganisms representatives of various taxonomic groups and their application for the creation of qualitatively novel ecological (remediatory) technologies.
Investigation of plants redox  (phenoloxidase and peroxidase ) and hydrolyzing (?-glucosi­dase) ensymes.    
Elaboration of industrial technologies for the production of biologically active composites and natural colorants of different colours (red, yellow, brown, black, etc.) from plant raw materials.

Research Activity

Collections of bacteria, yeasts and microscopic fungi including the forms of these  organisms growing in critical conditions (alkaline, acid and saline culture media and moderately high temperature-600C for microscopic fungi)  have been created.
The most active producers of enzymes have been selected, the condition for the production of stable carbohydrases (ordinary and heat resistant cellulases, ordinary and acid resistant amylases, proteases and other enzymes) have been worked out. Properties of these enzymes have been studied.
Invertase of fermentation yeasts (Saccharommyces cerevisie var. vini – 3a) has been studied. The role of Creb,s cycle ketoacids and the mechanism of ? – carboxylation in yeast cell has been studied. Hydrocarbonic skeleton transformations of proline, lysine, izoleucine, arginine and histidine in the fermentation medium during secondary alcoholic fermentation have been studied.
Chemical composition of intracellular soluble proteins, glucolipids and peptolipids of nocardia – like bacteria has been studied. The possibility of  use of  these microorganism as a chemotaxonomic criterium in systematics of this group of microorganisms has been shown.
By chemical mutagenesis the active strains, producers of ? – carotene and ? – group vitamins, which can be used in agriculture, have been obtained.
Microscopic fungi, bacteria and yeasts, capable to degrade the organic, ecological toxicants with different structures have been selected. They serve as a basis for the creation of a qualitatively novel remediatory technologies.   In cultures of these groups isolated from various soil – climatic zones and soils, contaminated with organic toxicants the strains capable to assimilate  various oil components, such as 2,4,6, - trinitrotoluene polychlorinated cyclic compounds, aromatic and polyaromatic hydrocarbons, different pesticides, etc. have been revealed.
From different plants (tea, vine, walnut. phenoloxidase, peroxidase and ? – glucosidase  have been isolated.  Physical-chemical properties and mechanism of action of these enzymes have been studied.      
From tea leaves and pomegranate skin natural inhibitors of phenoloxidase and peroxidase of phenolic nature have been isolated. Possibility of  use of  the natural inhibitor  from tea leaves to avoid undesirable oxidation (browning) reactions in fruit juice and other products has been established.
The industrial technologies of obtaining of biologically active composites and colorants of different colours (red, yellow, brown, black, etc.) from plant raw materials have been elaborated. Antioxidant  and antibacterial activities of natural colorants, prepared on the basis of tea leaves extract has been revealed.

Members:

  1. Kirtadze Engur - Doctor, professor, head of laboratory
  2. Kvesitadze Giorgi – Academician,chief scientist
  3. Mchedlishvili Nani – Doctor, senior scientist 
  4. Omiadze Nino - Doctor, senior scientist
  5. Kutateladze Lali – PhD,senior scientist
  6. Gagelidze Nino – PhD, senior scientist
  7. Khokhashvili Izolda – PhD, senior scientist
  8. Urushadze Tamar – PhD, senior scientist
  9. Tsereteli Alexander - PhD, scientist
  10. Gulua Levan - PhD, scientist
  11. Jobava Maya - PhD, scientist
  12. Daushvili Lela - PhD, scientist
  13. Amiranashvili Lia - PhD, scientist
  14. Khvedelidze Rusudan - PhD, scientist
  15. Alexidze Tinatin – PhD, lab assistant
  16. Iashvili Tamar – PhD, lab assistant
  17. Burduli Tamar – PhD, lab assistant
  18. Djalamidze Ilona – PhD, lab assistant
  19. Jimsheleishvili Tamar - PhD, lab assistant

Kirtadze Engur

1939 – Born.
1961 – Georgian Agriculture University.
1986 - Candidate of Biological Sciences.
1995 – Doctor of Biological Sciences.
2006 - Head of Laboratory.

Selected Publications

  1. Kirtadze E.G., Kalichava N.A., Jokharidze T.Z.. The main pathways of conversation of some amino acids of vine by yeasts in secondary alcohololic fermentation. Fifth International symposium. Abstracts of papers, Berlin, 1976, 475.
  2. Kirtadze E. Assimilation and conversation of C1-C6 volatile fatty acids and monoatomic C1-C8 normal alcohol with yeasts in the secondary alcoholic fermentation. 6th International symposium of yeast. 9-13 July 1984, Montpellier, France, Abstracts II, 5.
  3. Lagundaridze L.V., Kirtadze E.G., Study of ?-fructofuranozidase activity in the yeasts. 15th International specialized symposium the yeasts. Riga, September 30 – October 6, Abstracts, 1999, 81.
  4. Markozashvili K., Kirtadze E. Proline conversion during primary alcoholic fermentation. Proceedings of the Georgian Academy of Sciences, Biological Series, 1998, 24, 1-6, 253-257.
  5. Kirtadze E., Markozashvili K. 114C Proline assimilation by yeasts in secondary alcoholic fermentation. Bulletin of the Georgian Academy of Sciences, 1998, 158, 1, 144-146.
  6. Aplakov V., Kirtadze E. Lysine conversion during natural alcoholic fermentation. Proceedings of the Georgian Academy of Sciences, Biological Series, 1999, 25, 1-3, 17-20.
  7. Kirtadze E, Aplakov V. The role of wine basic components in lysine biosynthesis. Proceedings of the Georgian Academy of Sciences, Biological Series, 1999, 25, 1-3, 97-100.
  8. Aplakov V., Kirtadze E. Lysine biotransformation during secondary alcoholic fermentation. Bulletin of the Georgian Academy of Sciences, 2000, 162, 3, 564-566.
  9. Aplakov V., Kirtadze E. Lysine biosynthesis during natural alcoholic fermentation. Bulletin of the Georgian Academy of Sciences, 2002, 166, 2, 324-326.
  10. Aplakov V., Kirtadze E. Biotransformation of glutamic acids during alcoholic fermentation. Bulletin of the Georgian Academy of Sciences, 2003, 167, 1, 123-125.
  11. Aplakov V., Kirtadze E. Glucine and serine conversion during secondary alcoholic fermentation. Bulletin of the Georgian Academy of Sciences, 2003, 167, 2, 312-314.
  12. Gagelidze N., Amiranashvili L., Sulamanidze L., Alexidze T., Chrikishvili D., Kirtadze E. Microbial destructors of oil products. 8th International FZK/TNO Conference on Contaminated Soil, 12-16 May, 2003. Gent, Belgium. Conference proceedings  2647-2648.
  13. Varsimashvili Kh., Tinikashvili L., Amiranashvili L., Gagelidze N., Kirtadze E., Khatisashvili G., Gogoberidze M. Influence of some physicochemical factors in different microorganisms capable for degradation of 2,4,6-trinitrotoluene and mineral oil. Proceedings of the Georgian Academy of Sciences, Biological series B, 2004, 2. 3-4, 104-109.
  14. Tinikashvili L., Varsimashvili Kh., Gagelidze N., Amiranashvili L., Chrikishvili D., Kirtadze E., Khatisashvili G., Gogoberidze M.. Influence of temperature on growth and degradation ability of microorganisms capable for destruction of 2,4,6-trinitrotoluene and mineral oil. Proceedings of the Georgian Academy of Sciences, Biological series A, 2004, 30, 4, 493-497
  15. Gagelidze N., Amiranashvili L., Varsimashvili Kh., Tinikashvili L., Kirtadze E., Gogoberidze M.. Screening of strains capable for degradation of 2,4,6-trinitrotoluene. Bulletin of the Georgian Academy of Sciences, 2004, 169, 2, 381-384.
  16. Amiranashvili L., Gagelidze N., Tinikashvili L., Varsimashvili Kh., Chrikishvili D., Gelashvili N., Graves D., Kirtadze E., Ghoghoberidze M. and Kvesitadze G.. Selection of Soil Microorganisms Capable of Degrading Mineral Oil. Journal of biological physics and chemistry, 2005, 5, 2/3, 84-88.
  17. Kvesitadze G., Torok T., Kutateladze L., Gagelidze N., Amiranashvili L., Kvesitadze E., Kirtadze E., Kachlishvili E.. Collection of bacteria and filamentous fungy isolated from different soil-climatic zones in the Southern Caucasus. Proceedings of the annual general meeting of the European Culture Collections’ Organization (ECCO XXV) “The role of culture collections at the beginning of the XXIst century”. Budapest, Hungary, 2006,Yune 7-10, 93-106.
  18. Kirtadze E., Gagelidze N., Kiknadze M., Tusishvili Kh., Amiranashvili L.. Screening of yeasts, destructors of pesticides – 2,4-dichlorophenoxyacetic acid and its potassium salt. Proceedings of the Georgian Academy of Sciences, Biological series B., 2007, 5, 2, 66-70.
  19. Gagelidze N., Amiranashvili L., Sachaneli T., Jimsheleishvili T., Urushadze T., Khvedelidze R., Kirtadze E.. Extraction and screening of alcalophilic bacteria – alkaline proteases producents. Science and Technology Center in Ukraine Workshop “Plant and microbial enzymes: isolation, characterization and biotechnology applications”, 2007, 2-5th July  Tbilisi,85-88.

Monographs

  1. Kirtadze E., Kurdovanidze T. Biochemical peculiarities of secondary alcohol  fermentation. Tbilisi, 1992, 164.
  2. Gordeziani, M., Khatisashvili, G., Kirtadze, E. Bioenergetic and Regulation of Oxidative Processes. (Ed. G. Kvesitadze) Tbilisi, 2004. 245

Grants of the Georgian Academy of Sciences

  1. 1997 – 1999 – 14.1. Study of molecular mechanisms of organic xenobiotics detoxifications in lower and higher plants.
  2. 2000 – 2001 – 14.1. Study of metabolic peculiarities of microscopic fungi isolated from various soil – climatic zones of Georgia.
  3. 2002 – 2003 – 14.1.02. Creation of extremophilic microscopic fungi collection.
  4. 2004 – 2005 – 14.1.04. Establishment of microscopic fungi and bacteria detoxification capability.

International Grants

  1. 2001 – 2004 ISTC G-369 Elaboration of Methods of Bioremediation of Contaminated Soils on Former Military Locations and Proving Grounds in Georgia (www.istc.ru).
  2. 2002 – 2004 ISTC G-718 Elaboration of a new strategy of phytoremediation and long- term protection of the environment polluted by hydrocarbons (www.istc.ru).

Kvesitadze Giorgi

1942 - Born.
1964 - Graduated from Tbilisi State University, Department of Chemical Technology.
1969 - PhD, Moscow, Bach Institute of Biochemistry.
1980 - D.Sc., Moscow, Bach Institute of Biochemistry, Russian Academy of Sciences.
1978-1979 - Post doctoral research: University of Pennsylvania, Philadelphia, USA.
1983-1984 - Post doctoral research: Lehigh University, Bethlehem, USA.
1986 - Post doctoral research: Munich, Max Plank Institute of Biochemistry.

Personal

Academician-Secretary of the Department of Biology, Academy of Sciences of Georgia
Director of the Durmishidze Institute of Biochemistry and Biotechnology, Academy of Sciences of Georgia
Professor of Tbilisi State University and Georgian Technical University
Member of National Academy of Sciences
Member of Editorial Boards of: three international Journals (Fresenius Environmental Bulletin, Ecotoxicology and Environmental Safety, Journal of Biological Physics and Chemistry), two Journals of Russian Academy of Sciences (Biochemistry, Applied Biochemistry and Microbiology) and Journal of the Academy of Sciences of Georgia (Bulletin of the Georgian Academy of  Sciences.)
1999-2001 Associated member of NATO Life Sciences and Technologies Panel
2002 - Member of Israeli-France Hi-Tech Association
Expert of Euro Council in Biotechnology.
Held over 80 seminars in the USA, Germany, Belgium, Austria, France, England, Spain, Italy, etc.

Institutional Affiliations

1973 - Head of Biotechnology Department of the Institute of Plant Biochemistry, Academy of Sciences of Georgia, Tbilisi
1983-1987 - Deputy Director of the Institute of Plant Biochemistry Academy of Sciences of Georgia
1984-1987 - Deputy Chairman of Georgian Committee of Science and Technology
1987 - Director of the Institute of Plant Biochemistry (since1999 Durmishidze Institute of Biochemistry and Biotechnology)
1992-1994 - Minister of Agriculture and Food Processing of Georgia.
1994-1996 - Chief State Adviser in Science and Ecology.

Publications

Seven books; 220 scientific publications; 29 inventions; holder of 29 USSR, one USA, two Swiss and one German patents

Selected Publications

  1. Khatisashvili G., Kurashvili M., Gordeziani M., Kvesitadze G. Functional evolution of separate components of plant monooxigenase system involved in xenobiotic detoxication.Fresenius Environmental Bulleten, 1994, 3, 621-626.
  2. Papeta N., Kovalevich T, Nikolaishvili N., Chertov O., Tsilosani G., Kvesitadze G. Purification and characterization of bacterial toxin that inhibits the growth of phytopathogenic fungi.  Applied Biochemistry and Microbiology. 1994 ,30, 4-5, 480-483.
  3. Sadunishvili T., Gvarliani N., Nutsubidze N., Kvesitadze G. Effect of methionine sulfoximine on nitrogen metabolism and externally supplied ammonium assimilation in Kidney bean. Ecotoxicology and Environmental Safet, 1996, 34, 70-75.
  4. Kvesitadze G., Sadunishvili, T. Effect and mechanism of action of amino acid preparations of Inagrosa on ammonia assimilation and cell protein synthesizing apparatus in legumes. In: Proceedings of the Conference on Plant proteins from European crops. Food and Non-Food Applications. Nantes, France,  1996, 23-261.
  5. Kvesitadze E., Nizharadze D., Buachidze T., Kvesitadze G. Thermostability and Physical-Chemical Properties of Endo- and Exo-Glucanases of Thermophilic Fungi. Biochemistry (Moscow), 1997, 62, 2, 176-183.
  6. Kvesitadze G.I., Kvachadze L. L., Kvesitadze E. G. Selection of thermophilic cellulase-producing micromycetes. Applied Biochemistry and Microbiolog., 1997, 33, 2, 132-137.
  7. Khatisashvili G., Gordeziani M., Korte F., Kvesitadze G. Plant monooxygenases: participation in xenobiotic oxidation. Ecotoxicology and Environmental Safety, 1997, 36, 118-122.
  8. Ugrekhelidze D., Korte F., Kvesitadze G. Uptake and transformation of benzene and toluene by plant leaves. Ecotoxicology and Environmental Safety, 1997, 37, 24-29 .
  9. Ugrekhelidze D., Kvesitadze G. Assimilation and metabolism of methane by higher plant. Fresenius Environmental Bulleten, 1997, 6, 740-748.
  10. Buadze O., Kvesitadze G. Effect of low-molecular-weight alkanes on the plant cell photosynthetic apparatus. Ecotoxicology and Environmental Safety, 1997, 38, 36-44.
  11. Buadze O., Sadunishvili T., Kvesitadze G. The effect of 1, 2-benzantracene and 3, 4-benzpyrene on the ultrastructure of maize cells. International Biodeterioration and Biodegradation,  1998, 41/2, 119-125.
  12. Ugrekhelidze D., Kvesitadze G., Arziani B., Mitaishvili T., Pliziashvili U. Detoxication of phenol in annual plant seedlings, Ecotoxicology and Environmental Safety, 1999, 42, 119-124.
  13. Kvesitadze E., Adeishvili E., Gomarteli M., Kvachadze L., Kvesitadze G. Cellulase and xylanase activity of fungi in a collection isolated from the southern Caucasus. International Biodeterioration and Biodegradation, 1999, 43, 189-196.
  14. Korte F., Kvesitadze G, Ugrekhelidze D., Gordeziani M, Khatisashvili G., Buadze O., Zaalishvili G., Coulston F.  Organic toxicants and plants (Review), Ecotoxicology and Environmental Safety, 2000, 47, 1, 1-26.
  15. Gogoberidze M., Zaalishvili G., Khatisashvili G, Ugrekhelidze D., Gordeziani M., Kvesitadze G. Bioremediation – contemporary strategy of xenobiotics detoxification. Consoil 2000, The7th International FZK/TNO conference on contaminated soil, Conference proceeding, 2000, 1, 397- 404.
  16. Sadunishvili, T., Betsiashvili, M., Kuprava, N., Nutsubidze, N., Kvesitadze, G. Preparation of valuable food protein and amino acid mixtures from soybean. Biotechnology, 2000, 3, 226-228 .
  17. Zaalishvili G., Khatisashvili G., Ugrekhelidze D., Gordeziani M., Kvesitadze G. Plant potential for detoxification (Review), Applied Biochemistry and Microbiology, 2000, 36, 5, 443-451.
  18. Zaalishvili G., Lomidze E., Buadze O., Sadunishvili T., Tkhelidze P., Kvesitadze G. Electron microscopic investigation of benzidine effect on maize root tip cells ultrastructure, DNA synthesis and calcium homeostasis. International Biodeterioration and Biodegradation, 2000, 46, 2, 133-140.
  19. Elisashvili V, Parlar H, Kachlishvili E, Chichua D, Bakradze M, Kohreidze N, Kvesitadze G. Ligninolytic activity of basidiomycetes grown under submerged and solid-state fermentation on plant raw material (sawdust of grapevine cuttings). Advances in Food Sciences, 2001, 23, 3, 117-123.
  20. Kvesitadze G., Gordeziani M., Khatisashvili G., Sadunishvili T., Ramsden J. Review: Some aspects of the enzymatic basis of phytoremediation. Journal of Biological Physics and Chemistry,2001, 1, 2, 49-57.
  21. Arziani B., Ugrekhelidze D., Kvesitadze G. Detoxication mechanism of exogenous monatomic phenols in pea seedlings. Ecotoxicology and Environmental Safety, 2002, 51, 85-89.
  22. Betsiashvili M., Sadunishvili T., Gigolashvili G., Nutsubidze N., Kvesitadze G. Valuable food protein preparation from soybean. Advances in Food Sciences,  2002, 24, 20-23.
  23. Sadunishvili T., Omiadze N., Kvesitadze G., Rodriguez-Lopez J. N. Thermostability and storage of horseradish and tea plant peroxidases, VI International Plant Peroxidase Symposium, Murcia, 2002,  3-7 July, 289-291.
  24. Shalashvili A., Zambakhidze N., Ugrekhelidze D., Kvesitadze G., Leupold G.   Antioxidant activity of grape bioflavanoid and some flavanoids. Advances in Food Science, 2002, 24, 1, 24-29.
  25. Zaalishvili, G., Sadunishvili, T., Scalla, R. Laurent, F., Kvesitadze, G. Electron Microscopic Investigation of Nitrobenzene Distribution and Effect on Plant Root Tip Cells Ultrastructure. Ecotoxicology and Environmental Safety. 2002, 52, 3, 190-197.
  26. Omiadze N., Pruidze N., Mchedlishvili N., Gulua L., Abutidze M., Daushvili L.,  Kvesitadze G. Inhibition of tea Leaf phenoloxidase by sulfur dioxide. Bulletin of Georgian Academy of Sciences, 2004, 169, 1, 154-156.
  27. Omiadze N, Parlar H., Leupold G.,  Mchedlishvili N., Gulua L., Akhvlediani K.,  Abutidze M, Sadunishvili T., Rodriguez – Lopez J. N, Kvesitadze G. Inhibition of   apple phenoloxidase and peroxidase by natural phenolics of tea leaves. Advances in Food Sciences, 2004, 26, 1, 26-31.
  28. Kvesitadze G., Omiadze N., Mchedlishvili N., Gulua L., Akhvlediani K., Abutidze M.,Pruidze N. Inhibition of phenoloxidase and peroxidase by natural inhibitor from tea leaves. 6th European Symposium on Biochemical Engineering Science. Book of Abstracts, 2006, 27-30 August, Salzburg, Austria.
  29. Mchedlishvili N., Omiadze N., Gulua L., Kvesitadze G., Zaletok S., Orlovsky O., Gogol S., Samoylenko O. Antioxidant and anticarcinogenic composite from green Tea and red wine lees as food additive. IUFOST 13-th World Congress of Food Science and Technology “Food is Life.”2006, 17-21 September, Nantes, France, Abstract book.

Monographs

  1. Kvesitadze G., Kvesitadze E. Biotexnology. Ed.Kirtadze E., Shalashvili A., Tbilisi 1999,431.
  2. Gordeziani M., Kvesitadze G. Chemical basis for ecology. Ed. Ugrekhelidze D., Tbilisi 2000, 311.
  3. Kvesitadze G., Bezborodov A. Introduction into Biotexnology.  Mocow, Nauka  2002,284.
  4. Kvesitadze G. I., Khatisashvili G.A., Sadunishvili T.A., Evstigneeva Z.G. Metabolism of Anthropogenic Toxicants in Higher Plants. Maik Nauka, Moscow,  2005, 208.
  5.  Kvesitadze G., Khatisashvili G., Sadunishvili T., Ramsden J-J. Biochemical Mechanisms of Detoxification in Higher Plants-Basis of Phytoremediation, Springer, 2006, 263 .

Grants of the Georgian Academy of Sciences

  1. 1997-1999 14.1. Study of molecular mechanisms of organic xenobiotic detoxification in lower and higher plants.
  2. 1997 – 1999 – 14.5. Working out of scientific grounds for the realization of mycelial fungi biosynthesis potential to obtain enzymatic preparations.
  3. 2000 – 2001 – 14.1. Study of metabolic peculiarities of microscopic fungi isolated from various soil – climatic zones of Georgia.
  4. 2002 – 2003 – 14.1.02. Creation of extremophilic microscopic fungi collection.
  5. 2002 – 2003 – 14.5.02.   Isolation, properties and in vitro regulation of activity of phenoloxidase and peroxidase from green husk of walnut (Juglans regia).

International Grants

  • 1999-2001 – INTAS-Georgia 97-0716 Coordination of oxidative enzymes as a key factor in detoxification of organic xenobiotics in plants (www.intas.be).
  • 2000–2003 – INTAS Food 00 – 0727 Prevention of food spoilage by suppression of phenoloxidase, peroxidase and growth of pathogenic micro-flora by use of natural inhibitors of plant origin( www.intas.be).
  • 2001-2004 – ISTC G369 Elaboration of methods of bioremediation of contaminated soils on former military locations and proving grounds in Georgia (www.istc.ru).
  • 2002-2005 – ISTC G718 Elaboration of a new strategy of phytoremediation and long-term protection of the environment polluted by hydrocarbons (www.istc.ru).
  • 2003–2006 - STCU G-101  Creation of Collection of Extremophilic Mycelial Fungi                     Isolated from All Ecological Niches of the Caucasus, Investigation their             Pathogenicity and Elaboration of the Technologies Based on their Degradational, Oxidizing and Synthesizing Potential (www. istc.ru/).
  • 2005–2007 - STCU GG-122 Creating Plant Bio­concentrates with High Antira­diation and ­An­    ti­ca­rcinogenic Action on the Base of Polyphe­nols and Wor­king   out  Indust­rial Technology for Their Production  (www.stcu.kiev.ua/).
  • 2004–2007 - ISTC G-1129 Bacteriophage, an effective biological tool against plant diseases    caused by pathogenic bacteria (www.istc.ru).

Mchedlishvili Nani

1956 – Born
1978 - Tbilisi State University
1990 - Candidate of Biological Sciences
2004 – Doctor of Biological Sciences

Selected Publications

  1. Abutidze M., Pruidze G., Mchedlishvili N. purification and characterization of ?-glucosidase of tea leaves. Bulletin of Georgian Academy of Sciences, 1996, 154, 3, 454-455.
  2. Pruidze G.N., Omiadze N.T., Mchedlishvili N.I. Characterization of Monophenol Monooxygenase from Tea Leaves. Appl. Biochem. Microbiol. 1997,  33, 1,  45-56.
  3. Jincharadze M., Pruidze G., Omiadze N., Mchedlishvili N. Effect of tea leaf peptides on the monophenol monooxygenase and catechol oxidase activities. Bulletin of Georgian Academy of Sciences, 1998, 157, 3, 300-301.
  4. Mchedlishvili N.I., Pruidze G.N., Omiadze N.T., Zukhbaya R.V. Soluble and Immobilized Phenol Oxidase of the Fungus Mycelia sterilia IBR 35219/2: a Comparative Study.  Appl. Biochem. Microbiol. 2000, 36, 2, 138-142.
  5. Omiadze N.T., Pruidze G.N.,  Mchedlishvili N.I. Gulua L.K. Intracellular Localization and Characterization of Monohenol Monooxygenase of Tea Leaves. Ukrainian Biochem. J. 2000, 72, 22-27. 
  6. Abutidze M., Mchedlishvili N., Pruidze G. The effect of metal ions on tea leaves ? - glucosidase activity. Bulletin of Georgian Academy of Sciences, 2000,  161, 3, 525-526.
  7. Mchedlishvili N., Pruidze M., Omiadze N., Pruidze N. Selection of plant raw materials for obtaining the food red color and study of its pigments stability. Bulletin of Georgian Academy of Sciences, 2000, 162, 2 , 367-368.
  8. Gulua L.K., Pruidze G.N., Mchedlishvili N.I , Omiadze N.T.,  Pruidze N.G. A Novel catechol reductase catalitic activity of tea leaf phenol oxidase. Journal of Biological Physics and Chemistry ( JBPC), 2002, 2, ?, 89-94.
  9. Omiadze N., Bendeliani E., Pruidze G., Mchedlishvili N. Effect of tea leaf phenolic compounds on the activity of barley malt peroxidase. Bulletin of Georgian Academy of Sciences, 2002, 166, 1, 115-116.
  10. Pruidze G.N.,  Mchedlishvili N.I , Omiadze N.T., Gulua L.K., Pruidze N. G. Multiple forms of phenol oxidase from Kolkhida tea leaves (Camellia sinensis L.) and Mycelia sterilia IBR 35219/2 and their role in tea production. Food Research International, 2003, 36, 6, 587-595.
  11. Zamtaradze  R., Mchedlishvili N., Omiadze N., Pruidze G. Isolation  of  phenoloxidase from  green  husk  of  walnut (Juglans regia)  and  study  of  its  properties. Bulletin of Georgian Academy of Sciences, 2003, 167, 3, 519-520.
  12. Alyabyev A., Gordon L., Loseva N., Rachimova G., Tribunskih V., Estrina R., Sadunishvili T., Gulua L., Mchedlishvili N., Rodrigues-Lopez J.N. The Effect of a Natural Inhibitor Isolated from the Tea Leaf on the Energy Processes in Model Systems. Thermochimica Acta. 2004. 422. 1-2, 109-113
  13. Omiadze N, Parlar H., Leupold G.,  Mchedlishvili N., Gulua L., Akhvlediani K.,  Abutidze M, Sadunishvili T., Rodriguez – Lopez J. N, Kvesitadze G. Inhibition of   apple phenoloxidase and peroxidase by natural phenolics of tea leaves. Advances in Food Sciences, 2004, 26, 1, 26-31.
  14. Omiadze N., Pruidze N., Mchedlishvili N., Gulua L., Abutidze M., Daushvili L.,  Kvesitadze G. Inhibition of tea leaf phenoloxidase by sulfur dioxide. Bulletin of Georgian Academy of Sciences, 2004,  169, 1, 154-156.
  15. Zamtaradze  R., Mchedlishvili N., Omiadze N., Gulua L., Abutidze M., Kvesitadze    G. Monophenolase and diphenolase activities of phenoloxidase from walnut (Juglans regia L.) green husk. Bulletin of Georgian Academy of Sciences, 2004, 169, 1, 144-146.
  16. Omiadze N., Pruidze N., Mchedlishvili N., Gulua L., Abutidze M., Daushvili L.,  Kvesitadze G. Inhibition of tea leaf phenoloxidase by sulfur dioxide. Bulletin of Georgian Academy of Sciences, 2004, 169, 1, 154-156.
  17. Omiadze N., Mchedlishvili N.,  Gulua L.,  Pruidze N.,  Abutidze M. Study of multiple forms of phenol oxidase from Kolkhida tea leaves. Bulletin of Georgian Academy of Sciences, 2004, 170, 1, 155-157.
  18. Mchedlishvili N., Omiadze N., Gulua L. Nishnianidze N., Rekhviashvili M., Pruidze N. Dynamics of Accumulation of Tea Pigments during Tea (Camellia sinensis L.) Leaf Processimg. Proceedings of the Georgian Academy of Sciences, Biological Series,  2004, 2, 5-6, 1-4
  19. Bajinyan S. A.,  Kvesitadze  G. I., Malakyan M. H., Pogosyan A.S., Dallakyan A.M., Mchedlisvili N. I., Omiadze N., N.T., Gulua L. K.  Radiomodifying and cytogenetic activity of green tea extract. European Radiation Research 2004. The 33-rd Annual Meeting of the European Society for Radiation  Biology, August 25-28, 2004, Budapest, Hungary, 9.
  20. Mchedlisvili N., Omiadze N., Gulua L., Sadunishvili T., Zamtaradze  R., Abutidze M., Bendeliani E., Kvesitadze G. Thermostabilities of plant phenol oxidase and peroxidase determining the technology of their use in the food industry. Applied Biochemistry and  Microbiology, 2005, 41, 2, 165-170.
  21. Gulua L., Omiadze N., Mchedlisvili N., Chachua L. Tsiklauri G., Rekhviashvili M., Torbini V. Natural inhibitor of phenol oxidases and peroxidases from pomegranate peel.Proceedings of the Georgian Academy of Sciences, , Biological Series., 2005, 3, 1, 6-10.
  22. Zaletok S., Gulua L., Orlovsky A., Gogol S., Omiadze N., Mchedlisvili N., Kavetsky R. Effect of green tea extract on the growth of experimental breast tumours. Internatuional Research Conference on Food, Nutrition and Cancer. Poster Abstract Book, Washington, DC, July 14-15, 2005, 71.
  23. Khutsidze T., Gulua L., Mchedlishvili N.,Kvesitadze E., Omiadze N., Akhvlediani K., Abutidze M., Losaberidze P. Green tea extract as a stimulator of human  wounds recovery process. Proceedings of Georgian Academy of Sciences, Biological Series, 2006, 4, 3, 7-12.
  24. Gulua L., Shalamberidze M., Khutsidze T., Omiadze N., Mchedlishvili N., Abutidze M. Investigation of some biologically active compounds and antioxidant activity of green tea dry extract from Kolkhida tea leaves. Bulletin of Georgian Academy of Sciences, 2006, 173, 151-153.
  25. Kvesitadze G.., Omiadze N., Mchedlishvili N., Gulua L., Akhvlediani K., Abutidze M.,Pruidze N. Inhibition of phenoloxidase and peroxidase by natural inhibitor from tea leaves. 6th European Symposium on Biochemical Engineering Science, Book of Abstracts, 2006, 27-30 August, Salzburg, Austria.
  26. Vadachkoria N., Mchedlishvili N., Gakokidze R. Changes in  content of nitrogen, phosphorus and potassium in leaves of some Georgian sorts of Hazelnut in different vegetation periods. Proc. Georgian Acad. Sci., Biol. Ser. B. 2006, 4, 10-13.
  27. Mchedlishvili N., Omiadze N., Gulua L., Kvesitadze G., Zaletok S., Orlovsky O., Gogol S., Samoylenko O. Antioxidant and anticarcinogenic composite from green Tea and red wine lees as food additive. IUFOST 13-th World Congress of Food Science and Technology “Food is Life.” 2006, 17-21 September, Nantes, France, Abstract book.
  28. Omiadze N., Mchedlishvili N., Pruidze N., Gulua L.,  Abutidze M.,  Akhvlediani K., Kvesitadze E., Aplakov V. Regulation of phenoloxidase activity with sulfur dioxide as the base of production of high-quality instant green tea. Applied Biochemistry and  Microbiology, 2007, 43, 1, 21-24.
  29. Omiadze N.T., Aplakov V.R., Bendeliani E.G., Mchedlishvili N.I., Gulua L.K., Abutidze M.O., Tsiklauri G.Ch. Significance of phenoloxidase and peroxidase regulation in juices and beer production.  STCU Workshop - Plant & microbial enzymes: isolation, characterization & biotechnology applications, 2 -5 th July 2007 Tbilisi, Georgia

Patent of the USSR

N 1025135, 3. 04. 81. Method of production of food colorant from beet

Patent of Georgia

N1121, 20.09.93. Method of  production of colorant

Grants of the Georgian Academy of Sciences

  1. 1997 – 1999 – 14.3. Representatives of Georgian flora – a source of biologically active compounds.
  2. 2000 – 2001 – 14.5.  Investigation of mechanism of antioxidative action of natural inhibitors of tea and vine redox enzymes: isolation and use of them.
  3. 2002 – 2003 – 14.5.02.  Isolation, properties and in vitro regulation of activity of phenoloxidase and peroxidase from green husk of walnut (Juglans regia).
  4. 2004 – 2005 – 14.4.04. Investigation of regulation of enzyme activity of cell defense mechanism by oxidized products of polyphenolic compounds of  higher plants.

International Grants

  1. 2001 – 2004 – INTAS Food 00 – 0727. Prevention of food spoilage by suppression of phenoloxidase, peroxidase and growth of pathogenic micro-flora by use of natural inhibitors of plant origin. (http://www.intas.be/mainfs.htm)
  2. 2004 – 2006 STCU GG – 122. Creating plant bio­concentrates with high antira­diation and ­an­ti­ca­rcinogenic action on the base of polyphe­nols and wor­king   out  indust­rial technology for their production (www.stcu.kiev.ua/)
  3. 2007-2009 STCU-GNSF 4329. Biologically active food red colorant of plant origin

Grants of the Georgian Academy of Sciences

  1. 1997 – 1999 – 14.3. Representatives of Georgian flora – a source of biologically active compounds.
  2. 2000 – 2001 – 14.5.  Investigation of mechanism of antioxidative action of natural inhibitors of tea and vine redox enzymes: isolation and use of them.
  3. 2002 – 2003 – 14.5.02 . Isolation, properties and in vitro regulation of activity of phenoloxidase and peroxidase from green husk of walnut (Juglans regia).
  4. 2004 – 2005 – 14.4.04. Investigation of regulation of enzyme activity of cell defense mechanism by oxidized products of polyphenolic compounds of higher plants.

International Grants

  1. 2001 – 2004 – INTAS Food 00 – 0727. Prevention of food spoilage by suppression of phenoloxidase, peroxidase and growth of pathogenic micro-flora by use of natural inhibitors of plant origin. (http://www.intas.be/mainfs.htm)
  2. 2004 – 2006 STCU GG – 122.  Creating plant bio­concentrates with high antira­diation and ­an­ti­ca­rcinogenic action on the base of polyphe­nols and wor­king   out  indust­rial technology for their production (www.stcu.kiev.ua/)
  3. 2004 – 2007 ISTC G-1129. Bacteriophage, an effective biological tool against plant diseases caused by pathogenic bacteria. (www.istc.ru)
  4. 2007-2009 STCU-GNSF 4329. Biologically active food red colorant of plant origin

Omiadze Nino

1957 – Born
1981 – Georgian State University of Subtropical Husbandry
1990 - Candidate of Biological Sciences
2004–Doctor of Biological Sciences

Selected Publications

  1. Pruidze G., Jincharadze M., Varazashvili T., Omiadze N. Peptides of Black Tea Dry Concentrates and Their Aminoacid  Composition. Bulletin of Georgian Academy of Sciences. 1996,154,.3, 448-449.
  2. Pruidze G.N., Omiadze N.T., Mchedlishvili N.I. Characterization of Monophenol Monooxygenase from Tea Leaves. Appl. Biochem. Microbiol. 1997,  33, 1,  45-56.
  3. Jincharadze M., Pruidze G., Omiadze N., Mchedlishvili N. Effect of tea leaf peptides on the monophenol monooxygenase and catechol oxidase activities. Bulletin of Georgian Academy of Sciences. 1998, 157, 3, 300-301
  4. Mchedlishvili N., Pruidze M., Omiadze N., Pruidze N. Selection of plant raw materials for obtaining the food red color and study of its pigments stability. Bulletin of Georgian Academy of Sciences. 2000, 162, 2 , 367-368.
  5. Mchedlishvili N.I., Pruidze G.N., Omiadze N.T., Zukhbaya R.V. Soluble and Immobilized Phenol Oxidase of the Fungus Mycelia sterilia IBR 35219/2: a Comparative Study.  Appl. Biochem. Microbiol. 2000, 36, 2138-142.
  6. Omiadze N.T., Pruidze G.N.,  Mchedlishvili N.I. Gulua L.K. Intracellular Localization and Characterization of Monohenol Monooxygenase of Tea Leaves. Ukrainian Biochem. J. 2000, V.72., pp.22-27. 
  7. Gulua L.K., Pruidze G.N., Mchedlishvili N.I , Omiadze N.T.,  Pruidze N.G. A Novel catechol reductase catalitic activity of tea leaf phenol oxidase. Journal of Biological Physics and Chemistry ( JBPC). 2002, 2, ?, 89-94.
  8. Omiadze N., Bendeliani E., Pruidze G., Mchedlishvili N. Effect of tea leaf phenolic compounds on the activity of barley malt peroxidase. Bulletin of Georgian Academy of Sciences. 2002, 166, 1, 115-116.
  9. Pruidze G.N.,  Mchedlishvili N.I , Omiadze N.T., Gulua L.K., Pruidze N. G. Multiple forms of phenol oxidase from Kolkhida tea leaves (Camellia sinensis L.) and Mycelia sterilia IBR 35219/2 and their role in tea production. Food Research International. 2003, 36, 6, 587-595.
  10. Zamtaradze  R., Mchedlishvili N., Omiadze N., Pruidze G. Isolation  of  phenoloxidase from  green  husk  of  walnut (Juglans regia)  and  study  of  its  properties. Bulletin of Georgian Academy of Sciences. 2003, 167, 3, 519-520.
  11. Omiadze N, Parlar H., Leupold G.,  Mchedlishvili N., Gulua L., Akhvlediani K.,  Abutidze M, Sadunishvili T., Rodriguez – Lopez J. N, Kvesitadze G. Inhibition of   apple phenoloxidase and peroxidase by natural phenolics of tea leaves. Advances in Food Sciences 2004, 26, 1, 26-31.
  12. Omiadze N., Pruidze N., Mchedlishvili N., Gulua L., Abutidze M., Daushvili L.,  Kvesitadze G. Inhibition of tea leaf phenoloxidase by sulfur dioxide. Bulletin of Georgian Academy of Sciences. 2004,  169, 1, 154-156.
  13. Zamtaradze  R., Mchedlishvili N., Omiadze N., Gulua L., Abutidze M., Kvesitadze    G. Monophenolase and diphenolase activities of phenoloxidase from walnut (Juglans regia L.) green husk. Bulletin of Georgian Academy of Sciences. 2004, 169, 1, 144-146.
  14. Omiadze N., Pruidze N., Mchedlishvili N., Gulua L., Abutidze M., Daushvili L.,  Kvesitadze G. Inhibition of tea leaf phenoloxidase by sulfur dioxide. Bulletin of Georgian Academy of Sciences. 2004, 169, 1, 154-156.
  15. Omiadze N., Mchedlishvili N.,  Gulua L.,  Pruidze N.,  Abutidze M. Study of multiple forms of phenol oxidase from Kolkhida tea leaves. Bulletin of Georgian Academy of Sciences. 2004, 170, 1, 155-157.
  16. Mchedlishvili N., Omiadze N., Gulua L. Nishnianidze N., Rekhviashvili M., Pruidze N. Dynamics of Accumulation of Tea Pigments during Tea (Camellia sinensis L.) Leaf Processimg. Proceedings of the Georgian Academy of Sciences,  Biological Series.  2004. 2, 5-6, 1-4
  17. Bajinyan S. A.,  Kvesitadze  G. I., Malakyan M. H., Pogosyan A.S., Dallakyan A.M., Mchedlisvili N. I., Omiadze N., N.T., Gulua L. K.  Radiomodifying and cytogenetic activity of green tea extract. European Radiation Research 2004. The 33-rd Annual Meeting of the European Society for Radiation  Biology, August 25-28, 2004, Budapest, Hungary, 9.
  18. Mchedlisvili N., Omiadze N., Gulua L., Sadunishvili T., Zamtaradze  R., Abutidze M., Bendeliani E., Kvesitadze G. Thermostabilities of plant phenol oxidase and peroxidase determining the technology of their use in the food industry. Applied Biochemistry and  Microbiology. 2005, 41, 2, 165-170.
  19. Gulua L., Omiadze N., Mchedlisvili N., Chachua L. Tsiklauri G., Rekhviashvili M., Torbini V. Natural inhibitor of phenol oxidases and peroxidases from pomegranate peel. Proceedings of the Georgian Academy of Sciences, , Biological Series.  2005, 3, 1, 6-10.
  20. Zaletok S., Gulua L., Orlovsky A., Gogol S., Omiadze N., Mchedlisvili N., Kavetsky R. Effect of green tea extract on the growth of experimental breast tumours. Internatuional Research Conference on Food, Nutrition and Cancer. Poster Abstract Book. Washington, DC, July 14-15, 2005,  71.
  21. Khutsidze T., Gulua L., Mchedlishvili N.,Kvesitadze E., Omiadze N., Akhvlediani K., Abutidze M., Losaberidze P. Green tea extract as a stimulator of human  wounds recovery process. Proceedings of Georgian Academy of Sciences. Biological Series. 2006, 4, 3, 7-12.
  22. Gulua L., Shalamberidze M., Khutsidze T., Omiadze N., Mchedlishvili N., Abutidze M. Investigation of some biologically active compounds and antioxidant activity of green tea dry extract from Kolkhida tea leaves. Bulletin of Georgian Academy of Sciences. 2006, 173, 151-153.
  23. Kvesitadze G.., Omiadze N., Mchedlishvili N., Gulua L., Akhvlediani K., Abutidze M.,Pruidze N. Inhibition of phenoloxidase and peroxidase by natural inhibitor from tea leaves. 6th European Symposium on Biochemical Engineering Science. Book of Abstracts. 2006, 27-30 August, Salzburg, Austria.
  24. Mchedlishvili N., Omiadze N., Gulua L., Kvesitadze G., Zaletok S., Orlovsky O., Gogol S., Samoylenko O. Antioxidant and anticarcinogenic composite from green Tea and red wine lees as food additive. IUFOST 13-th World Congress of Food Science and Technology “Food is Life.” 17-21 September, Nantes, France. Abstract book.
  25. Omiadze N., Mchedlishvili N., Pruidze N., Gulua L.,  Abutidze M.,  Akhvlediani K., Kvesitadze E., Aplakov V. Regulation of phenoloxidase activity with sulfur dioxide as the base of production of high-quality instant green Tea. Applied Biochemistry and  Microbiology. 2007, 43, 1, 21-24.
  26.  Omiadze N.T., Aplakov V.R., Bendeliani E.G., Mchedlishvili N.I., Gulua L.K., Abutidze M.O., Tsiklauri G.Ch. Significance of phenoloxidase and peroxidase regulation in juices and beer production.  STCU Worksho-- Plant & microbial enzymes: isolation, characterization & biotechnology applications. 2 -5 th July 2007 Tbilisi, Georgia

Patent of Georgia

N1121, 20.09.93. Method of  production of colorant

Kutateladze Lali

1956 – Born
1978 - Tbilisi State University
1990 - Candidate of Biological Sciences

Selected Publications

  1. Tabagari M., Kutateladze L., Kvachadze L. The Selection of Conditions for Deep Cultivation for Glucoamylase Synthesis of A.awamori L-56.  Proceedings of the Academy of Sciences of the Georgian SSR, 1998, 1-6, 65-69.
  2. Bendeliani E., Pruidze G., Pruidze G., Kutateladze L. Isolation and   Study of Amylase     from Barley Malt. Bulletin of Georgian Academy of Sciences, 2001, 164, 2, 107-109. 
  3. Tabagari M., Kutateladze L., Aleksidze T., Chkartishvili D. Selection of Thermo-and Acid-stable Amylases and the Perspectives of Application of the Obtained Enzymes. Bulletin of the Georgian Academy of Sciences, 2001, 164, 3, 540-543.
  4. Gagelidze N., Amiranashvili L., Kutateladze-Sulamanidze L., Alexidze T., Chrikishvili D., Kirtadze E. Microbial Destructors of Oil Products. 8th International FZK/TNO Conference on Contaminated Soil. Gent, Belgium, 12-16 May, Conference Proceedings, 2003, 2647-2648.
  5. Kvesitadze G., Kutateladze L., Aleksidze T., Sadunishvili T., Kvesitadze E. Extremophylic microscopic Fungi from the southern slopes of the Caucasus - producers of stable enzymes. FEMS congress, Slovenia, Ljubljana, June 29 – July 3, Abstract Book, 2003, 43.   
  6. Kvesitadze G., L. Kutateladze, T. Aleksidze, N. Sabashvili, M. Jobava Extremophylic microscopic Fungi Producers of Stable Enzymes.Euro Congress, October 2003, Tashkent
  7. Tsulukidze T. Khokhashvili I, Kutateladze L., Sabashvili N. Assimilation and Degradation of 2,4,6-Trinitrotoluene   by Microscopic Fungi. Bulletin of the Georgian Academy of Sciences, 2004, 169, 2, 371-374.
  8. Iashvili T., Zakariashvili N., Burduli T., Kutateladze L. Conversion of Cellulose-Containing Wastes by Chaetomium thermophile T-1 into Protein-Rich  Biomass. Bulletin of the Georgian Academy of Sciences, 2004, 169, 1, 141-143.
  9. Kutateladze L., T. Iashvili, N. Zakariashvili, T. Aleksidze, N. Sabashvili, V. Aplakov, I. Khokhashvili, M. Jobava. Isolation and Identification of Microscopic Fungi from Some Soil – Climatic Zones of the Caucasus. Proceedings of the Georgian Academy of  Sciences,   2004, 2, 5-6, 74-78.
  10. Daushvili L., N. Zakariashvili, L. Kutateladze, M. Jobava, T. Iashvili, T. Burduli. Screening of Microscopic Fungi of Genus Aspergillus under the Extremal Conditions for the Purpose of Cellulase Producers Revealing. Bulletin of Georgian Academy of Sciences,  2004, 170, 1, 166-169.
  11. Kachlishvili E., N. Tsiklauri, E. Metreveli, G. Songulashvili, M. Asatiani, L. Kutateladze, N. Aladashvili. Identification and Reception of Pure Culture of the Cellulose Degrading Basidiomycetous Fungi From Diverse Ecological Niches of Georgia. Proceedings of the Georgian Academy of  Sciences, 2004, 2, 5-6, 16-21.
  12. Daushvili L., L. Kutateladze, T. Burduli, M. Jobava, I. Dzalamidze, T. Aleksidze, L. Tinikashvili. Microscopic Fingi from Various Regions of Georgia. Proceedings of the Georgian Academy of  Sciences,  2004, 2, 5-6, 68-74.
  13. Tsukukidze T.Khokhashvili I, Kutateladze L., Jobava. Biodegratation of Mineral Oil by Microscopic Fungi. Bulletin of the Georgian Academy of Sciences, 2004, 170, 2, 359-362.
  14. Khatisashvili G., G.Kvesitadze, G. Adamia, H. Gagelidze, L.Kutateladze-Sulamanidze, D. M. Tabagari, L. Kutateladze, I0 Khokhashvili, M.Abashidze, M. Jobava -Production of Liquid Sugars from Starch-containing Substrates using the Amylase Preparations. Bulletin of the Georgian Academy of Sciences, 171, 3,.551-557, 2005.
  15. Kvesitadze E., M. Kharebashvili., I. Khokhashvili., L. Kutateladze., N. Sabashvili., T. Aleksidze. Microscopic Fungi Producers of Proteolitic Enzymes. Proceedings of the Georgian Academy of  Sciences,  2005, 3, 3, 56-61.
  16. Abashidze M., I. Khokhashvili L. Kutateladze, M. Cheshmaritashvili. Obtaing of Enzymatic Hydrolysates from Wheat Flour Using Thermophilic Microorganisms Cellulases. Proceedings of the Georgian Academy of  Sciences,2006, 4, 2, 31-34.
  17. Daushvili L., L. Kutateladze, T. Burduli, M. Jobava, R. Khvedelidze. Acidophilic and Alkaliphilic Microscopic Fungi Isolated from Soils of Different Regions of Georgia. . Proceedings of the Georgian Academy of  Sciences,  2006, 4, 2, 89-92.
  18. Laskhishvili M., Zakhariashvili N., Kutateladze L.,  Khokhashvili I., Daushvili L., Kvesitadze E. Isolation and Identification of Microscopic Fungi from Salty Soils of  Kakheti.Proceedings of the Georgian Academy of  Sciences, 2006,4 1, 72-76.
  19. Kutateladze l., Iashvili T., Zakariashvili N., Daushvili L., Jobava M. The Caracterization of Glucoamylase from the Microfungus Aspergillus awamori L-56.Proceedings of the Georgian Academy of  Sciences,  2004, 2, 1-2, 12-15.
  20. Jobava M., Gomarteli M., Khokhashvili I., Kutateladze l., Zakariashvili N., Aplakov V. Mutant Strain of Penicilium canescens with High Xylanase Activity. Proceedings of the Georgian Academy of  Sciences,  2004, 2, 3-4, 29-32.
  21. Sadunishvili T., Kutateladze L., Torok T., Kvesitadze G. Extremophilic microorganisms from the Southern slopes of the Caucasus Mountains. Rim Summit on Industrial Biotechnology and Bioenergy submission, January 11-13, 2006, Honolulu, Hawaii, USA.
  22. Zakariashvili N., Kutateladze L., Iashvili T., Burduli T., Glonti N. Halopilic Microscopio Fungi from Soils of Sumid-Subtropical Continental and Subalpine Climatic Zones of Georgia. Bulletin of the Georgian Academy of Sci,  2006, 173, 1, 5-24.
  23. Daushvili L., Kutateladze L., Burduli T., JobavaM., DzalamidzeI., Urushadze T.,   Aleksidze T. Halophilic Micromycetes from Different Soil-climatic zones of Georgia. Bulletin of the Georgian Academy of Sciences, 2006, 173, 2, 359-362.
  24. Abashidze M., Khokhashvili I., Silagadze M., Kutateladze L. Application of Sugared Enzymatic Hydrolyzates in Baking and Confectionary Industry. Proceedings of the Georgian Academy of  Sciences,  2006, 4, 3, 99-103.
  25. Tsereteliu A., Kutateladze L., Zakariashvili N., Aleksidze T. Mycelial Fungi Pectinase Isolated from the Soils of Different Regions of Georgia. Bulletin of the Georgian Academy of Sciences, 2006, 174, 3, 513-516.
  26. Daushvili L., Kutateladze L., Burduli T., Kvesitadze E. Psychrophilic Microscopic Fungi of Subalpine Zone (Oni Region) of Georgia. Bulletin of the Georgian Academy of Sciences, 2006, 174, 3,  516-520.
  27. Urushadze T., Khvedelidze R., Kutateladze L., Berulava A. Investigation oh pH and Thermostability of Hydrolyzing Enzymes Produced by Micromycetes Growing in Extreme conditions. Bulletin  of the Georgian Academy of Sciences, 2006, 174, 3,  506-510.
  28. Daushvili L., Kutateladze L., Burduli T., Jobava M., Dzalamidze I. Thermophilic microscopic   fungi of soils of East Georgia. Proceedings of the Georgian Academy of  Sciences,  2007, 5, 1, 49-53.
  29. Zakariashvili N., Kutateladze L., Jobava M., Khokhashvili I., Dzalamidze I.,. Kvesitadze E., Aleksidze T. Study of the extent of extremophilocy of halophilic nicroscopic fungi from saline soils of Kakheti plain. Proceedings of the Georgian Academy of  Sciences, 2007, 5, 1, 59-64.
  30. Kvesitadze G., Torok T., Kutateladze L., Gagelidze N., Amiranashvili L., Kvesitadze E. Collection of bacteria and filamentous fungy isolated from different soil-climatic zones in Southern Caucasus. Proceeding of the annual meeting of the European Culture Collections’ Organization (ECCO XXV) “The role of culture collections at the beginning of the XXIst century”, Budapest, Hungary, Yune 7-10, 2006, 93-106.
  31. Sadunishvili T., Torok T., Kutateladze L., Gagelidze N., Pataraia D., Kvesitadze E. Collection of extremophilic microorganisms from the area of Caucassus - source for stable enzymes. Science and Technology Center in Ukraine Workshop. Plant and microbial enzymes: isolation, characterization and biotechnology applications, 2-5th July 2007, Tbilisi, 79-84.
  32. Kvesitadze E., Torok T., Urushadze T., Khvedelidze R., Kutateladze L., Kvesitadze G. Cellulases from thermophilic fungi. Science and Technology Center in Ukraine Workshop. Plant &Microbial enzymes: isolation, characterization & biotechnology applications, 2-5 July 2007, Tbilisi, Georgia. 71-74.

Grants of the Georgian Academy of Sciences

  1. 2000 – 2001 – 14.1. Study of metabolic peculiarities of microscopic fungi isolated from various soil – climatic zones of Georgia.
  2. 2002 – 2003 – 14.1.02 . Creation of extremophilic microscopic fungi collection.
  3. 2004 – 2005 – 14.1.04.  Establishment of microscopic fungi and bacteria detoxification capability.

National Grant

2006-2009 - GNSF/ST06/-087.  Creation of mycelial fungi collection from various soil – climatic zones of Georgia and selection of industrial strains.

International Grants

  1. 2001 – 2004 ISTC  369 Elaboration of Methods of Bioremediation of Contaminated Soils on Former Military Locations and Proving Grounds in Georgia. (www.istc.ru).
  2. 2003 – 2006 STCU G-101 Creation of collection of extremophilic mycelial fungi Isolated from all ecological niches of the Caucasus, investigation of  their pathogenicity and elaboration of the technologies based on their degradatinal, oxidizing and synthesizing potential  (www. istc.ru/)
  3. 2004 – 2005 STCU P-196. Microbial diversity for novel biotechnology applications. (www.stcu.int ).
  4. 2006 – 2009 STCU3740.  Development of tech­no­logies of basidiomy­cetes  ligninolytic enzy­­mes production, dyes decolorization and TNT polluted soil bio­re­radiation (www.stcu.int ).
  5. 2006 – 2008 CRDF_SCCRP, SCI-010002-SC-05. Establishment of a Biotechnological Network of Regional Microbial Culture Collections in the Caucasus. (www.crdf.org).
  6. 2006 – 2009 STCU 3802. Novel approach for the improvement of ecological guarantee of oil pipelines. (www.stcu.int ).

Gagelidze Nino

1954 – Born
1981 - Tbilisi State University
1992 - Candidate of Biological Sciences

Selected Publications

  1. Daraselia G.Y., Gagelidze N., Konicek J., Konichkova-Radochova M., Amiranashvili L. Composition of intracellular soluble proteins in Mycobacterium “rubrum” and its mutants. Folia microbiol., 1991, 36, 2, 144-147.
  2. Amiranashvili L., Buadze M., Tsotsoria T., Gagelidze N., Tinikashvili L., Khachapuridze E., Daraselia G. Characterization of peptidolipids in Mycobacteria and Rhodococci. Bulletin of the Georgian Academy of Sciences, 2001, 163, 1, 160-163.
  3. Gagelidze N., Amiranashvili L., Tinikashvili L., Batsikadze G., Kirtadze E. Isolation of microorganisms from the soils of military grounds of Georgia contaminated with organic toxicants. Proceedings of the Georgian Academy of Sciences. Biological series A, 2002, 28, 3-4, 253-257.
  4. Gagelidze N., Amiranashvili L., Sulamanidze L., Alexidze T., Chrikishvili D., Kirtadze E. Microbial destructors of oil products.  8th International FZK/TNO Conference on Contaminated Soil. Gent, Belgium. Conference proceedings, 2003,11 – 16, 2647-2648.
  5. Varsimashvili Kh., Tinikashvili L., Amiranashvili L., Gagelidze N., Kirtadze E., Khatisashvili G., Gogoberidze M.. Influence of some physicochemical factors in different microorganisms capable for degradation of 2,4,6-trinitrotoluene and mineral oil. Proceedings of the Georgian Academy of Sciences, Biological series B, 2004, 2, 3-4,104-109.
  6. Tinikashvili L., Varsimashvili Kh., Gagelidze N., Amiranashvili L., Chrikishvili D., Kirtadze E., Khatisashvili G., Gogoberidze M.. Influence of temperature on growth and degradation ability of microorganisms capable for destruction of 2,4,6-trinitrotoluene and mineral oil. Proceedings of the Georgian Academy of Sciences, Biological series A, 2004, 30, 4, 493-497.
  7. Gagelidze N., Amiranashvili L., Varsimashvili Kh., Tinikashvili L., Kirtadze E., Gogoberidze M.. Screening of strains capable for degradation of 2,4,6-trinitrotoluene. Bulletin of the Georgian Academy of Sciences, 2004, 169, 2, 381-384.
  8. Amiranashvili L., Gagelidze N., Tinikashvili L., Varsimashvili Kh., Chrikishvili D., Gelashvili N., Graves D., Kirtadze E., Ghoghoberidze M. and Kvesitadze G.. Selection of Soil Microorganisms Capable of Degrading Mineral Oil. Journal of biological physics and chemistry,2005, 5, 2/3, 84-88.
  9. Zakariadze N., Gagelidze N., Amiranashvili L., Nabakhtiani G., Tsigroshvili Z.. Bioindication of soil samples from contaminated military sites in Georgia. 9th International FZK/TNO Conference on Soil-Water Systems. 3-7 October. 2005. Bordeaux (France). ISTC Science workshops at the conference, 2005, 78-94.
  10. Kvesitadze G., Torok T., Kutateladze L., Gagelidze N., Amiranashvili L., Kvesitadze E., Kirtadze E., Kachlishvili E.. Collection of bacteria and filamentous fungy isolated from different soil-climatic zones in the Southern Caucasus. Proceedings of the annual general meeting of the European Culture Collections’ Organization (ECCO XXV) “The role of culture collections at the beginning of the XXIst century”. Budapest, Hungary, Yune 7-10, 2006, 93-106.
  11. Gagelidze N., Amiranashvili L., Jimsheleishvili T., Sachaneli T., Varsimashvili Kh., Tinikashvili L.. Isolation and selection of extremophilic bacteria, degrading sodium pentachlorophenolate, isolated from different soil-climatic zones of Georgia. Proceedings of the Georgian Academy of Sciences, 2007, 5, 2, 51-56.
  12. Kirtadze E., Gagelidze N., Kiknadze M., Tusishvili Kh., Amiranashvili L. Screening of yeasts, destructors of pesticides – 2,4-dichlorophenoxyacetic acid and its potassium salt. Proceedings of the Georgian Academy of Sciences, 2007, 5, 2, 66-70.
  13. Sadunishvili T., Torok T., Kutateladze L., Gagelidze N., Pataraia D., Kvesitadze E. Collection of extremophilic microorganisms from the area of Caucassus source for stable enzymes. Science and Technology Center in Ukraine Workshop “Plant and microbial enzymes: isolation, characterization and biotechnology applications”, 2-5th July 2007, Tbilici, 79-84.
  14. Gagelidze N., Amiranashvili L., Sachaneli T., Jimsheleishvili T., Urushadze T., Khvedelidze R., Kirtadze E. Extraction and screening of alcalophilic bacteria – alkaline proteases producents. Science and Technology Center in Ukraine Workshop “Plant and microbial enzymes: isolation, characterization and biotechnology applications”, 2-5th July 2007, Tbilici, 85-88.

Grants of the Georgian Academy of Sciences

  1. 1997–1999 – 14.1 Study of molecular mechanisms of organic xenobiotics detoxifi­ca­tions in lower and higher plants.
  2. 2000–2001 – 14.1 The study of metabolic peculiarities of microscopic fungi isolated from various soil – climatic zones of Georgia.
  3. 2002–2003 – 14.1.02 Creation of extremophilic microscopic fungi collection.
  4. 2004–2005 – 14.1.04 Establishment of microscopic fungi and bacteria detoxification capability.

International Grants

  1. 2001–2004 - ISTC 369 Elaboration of Methods of Bioremediation of Contaminated Soils on Former Military Locations and Proving Grounds in Georgia (www.istc.ru).
  2. 2004-2007 - STCU P-196 Microbial diversity for novel biotechnology applications (www.stcu.int ).
  3. 2004-2006 - STCU P-196 Microbial diversity for novel biotechnology applications (http.//www. stcu.int).
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